Speaker: Edward Hsu

Title: Magnetic Resonance Microscopy: From Single Cells to Small Animals

Edward Hsu, PhD^?, Department of Bioengineering

Spatial resolution of magnetic resonance imaging (MRI) has reached the microscopic, enabling anatomical and physiological examinations of large single cells and small animals. Moreover, the sensitivity to the tissue microstructure of the so-called MR diffusion tensor imaging (DTI) can be used to evaluate the organization of ordered tissues such as the brain white matter and myocardial fiber architecture. These tools are useful for understanding the basis of MRI observations of diseases, for example the diffusion-weighted hyperintensity associated with acute cerebral infarction, as well as evaluating structural and functional phenotypes of genetically manipulated animals. In this talk, general technical considerations of MR microscopy and DTI and examples of their applications will be discussed.